|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Purified human Alpha-1-Antitrypsin.|
|Storage buffer||PBS, pH 7.2, with 0.02% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Neat|
|Immunohistochemistry (Paraffin) (IHC (P))||Neat|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-90438 detects the 51 kD human alpha-1-antitrypsin. It does not cross-react with the alpha-1-acid glycoprotein, serum albumin, or other serum proteins.
MA1-90438 has been successfully used in immunohistochemistry (paraffin tissue), immunohistochemistry (frozen tissue) applications. Prolonged fixation in buffered formalin can destroy the epitope.
The MA1-90438 immunogen is purified human Alpha-1-Antitrypsin.
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells.
MA1-90438 was used in immunocytochemistry to study isolation of hepatocytes derived from human pluripotent stem cells by asialoglycoprotein receptor 1 as a specific cell-surface marker
|Peters DT,Henderson CA,Warren CR,Friesen M,Xia F,Becker CE,Musunuru K,Cowan CA||Development (Cambridge, England) (143:1475)||2016|
Mouse liver repopulation with hepatocytes generated from human fibroblasts.
MA1-90438 was used in immunocytochemistry to report the generation of human fibroblast-derived hepatocytes that can be used to repopulate mouse livers.
|Zhu S,Rezvani M,Harbell J,Mattis AN,Wolfe AR,Benet LZ,Willenbring H,Ding S||Nature (508:93)||2014|