OriGene

ABAT Monoclonal Antibody (UMAB178), UltraMAB™

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Datasheet

Protocols

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Tech Support

Product Image Gallery

ABAT Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent staining of HepG2 cells using anti-ABAT mouse monoclonal antibody (UM800070, green, 1:50). Actin filaments were labeled with Alexa Fluor 594 Phalloidin (red), and nuclear with DAPI (blue).

ABAT Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of paraffin-embedded human liver using ABAT clone UMAB178, mouse monoclonal antibody at 1:200 dilution of 1mg/mL using Polink2 Broad HRP DAB for detection. UM800070 requires heat-induced epitope retrieval with citrate pH6.0 at 110°C for 3 min using pressure chamber/cooker. The image shows strong cytoplasmic and membranous staining of hepatocytes no staining in the bile duct.

ABAT Antibody in Western Blot (WB) — Western blot analysis of extracts (15 µg) from 9 Human tissue by using anti-ABAT monoclonal antibody (1: Testis; 2: Uterus; 3: Breast; 4: Brain; 5: Liver; 6: Ovary; 7: Thyroid gland; 8: colon:;9:Spleen). (1:500.) Dilution: 1:500.

ABAT Antibody in Peptide array (ARRAY) — OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-ABAT mouse monoclonal antibody (UM800070). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification. (1:100)

Product Details

UM800070

Applications	Tested Dilution	Publications
Immunohistochemistry (Paraffin) (IHC (P))	1:100-1:200	-
Immunocytochemistry (ICC/IF)	1:100-1:200	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	UMAB178
Immunogen	Human recombinant protein fragment corresponding to amino acids 29-323 of human ABAT produced in E.coli. View immunogen
Conjugate	Unconjugated
Form	liquid
Concentration	0.5-1.0 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 1% BSA, 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Target Information

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate transaminase; FLJ17813; FLJ30272; GABA aminotransferase; GABA AT; GABA T; GABA transaminase; GABA transferase; GABA-AT; Gamma-amino-N-butyrate transaminase; hCG1984265; L AIBAT; L-AIBAT

Gene Aliases: ABAT; GABA-AT; GABAT; NPD009

UniProt ID: (Human) Q8N5W2

Entrez Gene ID: (Human) 18

Molecular Function: transaminase

Function(s)

response to hypoxia aging copulation locomotory behavior gamma-aminobutyric acid biosynthetic process gamma-aminobutyric acid catabolic process response to iron ion negative regulation of gamma-aminobutyric acid secretion cerebellum development positive regulation of heat generation positive regulation of insulin secretion negative regulation of dopamine secretion response to nicotine exploration behavior neurotransmitter catabolic process response to drug response to ethanol negative regulation of blood pressure positive regulation of dopamine metabolic process behavioral response to cocaine positive regulation of uterine smooth muscle contraction negative regulation of platelet aggregation positive regulation of inhibitory postsynaptic potential positive regulation of prolactin secretion positive regulation of aspartate secretion

Process(es)

4-aminobutyrate transaminase activity pyridoxal phosphate binding succinate-semialdehyde dehydrogenase binding protein homodimerization activity metal ion binding (S)-3-amino-2-methylpropionate transaminase activity iron-sulfur cluster binding

ABAT Monoclonal Antibody (UMAB178), UltraMAB™

Product Details

UM800070

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Target Information

References (0)

Bioinformatics

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