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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment contains a sequence corresponding to a region within amino acids 53 and 367 of SSH3BP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-34783 targets ABI1/SSH3BP1 in WB applications and shows reactivity with Human, Mouse, and Rat samples.
The PA5-34783 immunogen is recombinant fragment contains a sequence corresponding to a region within amino acids 53 and 367 of SSH3BP1.
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Abelson interactor 1; ABI-1; Abl interactor 1; Abl-binding protein 4; abl-interactor 1; Abl-interactor protein 1 long; ABLBP4; Ablphilin-1; E3B1; eps8 binding protein; eps8 binding protein (e3B1), alternatively spliced; Eps8 SH3 domain-binding protein; Eps8-binding protein; interactor protein AblBP4; nap1 binding protein; Nap1-binding protein; NAP1BP; spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; SSH3BP; SSH3BP1
ABI-1; ABI1; ABLBP4; E3B1; NAP1; NAP1BP; SSH3BP; SSH3BP1