|Tested species reactivity||Guinea pig, Goat, Pig, Rabbit, Dog, Human, Cat, Non-human primate, Sheep|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Denatured human kidney angiotensin converting enzyme.|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:100|
|Western Blot (WB)||1/50-1/100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-20316 detects angiotensin converting enzyme in human, feline, canine, guinea pig, rabbit, goat, ovine, porcine, and non-human primate samples.
MA1-20316 has been successfully used in ELISA, immunohistochemistry (paraffin), and Western blot procedures.
The MA1-20316 immunogen is denatured human kidney angiotensin converting enzyme.
ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.