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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (QVDFNRRADSLQKNQ) corresponding to the internal amino acids of ACO1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-0.3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
Aconitase 1, also known as iron regulatory element binding protein 1 , is a cytosolic protein which binds to iron-responsive elements . IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ACO1; aconitase 1; aconitase 1, soluble; aconitate hydratase; aconitate hydratase, cytoplasmic; ACONS; citrate hydro-lyase; cytosplasmic aconitase; epididymis luminal protein 60; ferritin repressor protein; IRE-BP 1; IREB1; IREBP; IREBP1; iron regulatory protein 1; iron-responsive element binding protein 1; iron-responsive element-binding protein 1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; soluble aconitase
ACO1; ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1