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FIGURE: 1 / 7
ACVR2B Antibody (MA5-60774) in ICC/IF
Immunocytochemistry analysis of ACVR2B in SH-SY5Y cells. Samples were incubated with ACVR2B Recombinant Monoclonal antibody (Product # MA5-60774) using a dilution of 1:100 followed by FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L). Counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.
Product Details
MA5-60774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Human
/ IgG1
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
7E5
Immunogen
Recombinant Human ACVR2A & ACVR2B protein.
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IIB; activin A receptor, type IIB; Activin receptor type IIB; Activin receptor type-2B; ACTR-IIB; MGC116908
Gene Aliases: ActR-IIB; ACTRIIB; ACVR2B; HTX4
UniProt ID: (Human) Q13705, (Mouse) P27040
Entrez Gene ID: (Human) 93, (Mouse) 11481
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
activin receptor activity, type II
growth factor binding
inhibin binding
metal ion binding
activin binding
nucleotide binding
protein kinase activity
transmembrane receptor protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transforming growth factor beta binding
serine/threonine protein kinase receptor
negative regulation of transcription from RNA polymerase II promoter
gastrulation with mouth forming second
kidney development
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
determination of left/right symmetry
mesoderm development
heart development
response to glucose
post-embryonic development
anterior/posterior pattern specification
signal transduction by protein phosphorylation
insulin secretion
lung development
positive regulation of bone mineralization
BMP signaling pathway
pancreas development
activation of protein kinase activity
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
organ growth
odontogenesis of dentin-containing tooth
positive regulation of osteoblast differentiation
embryonic foregut morphogenesis
skeletal system morphogenesis
palate development
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
skeletal system development
protein phosphorylation
pattern specification process
regulation of signal transduction
phosphorylation
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