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Product Details
MA5-38439
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6C3C7
Immunogen
Purified recombinant fragment of human ADAM10 (aa: EXTRA(20-119)) expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2898353
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; metalloendopeptidases
Gene Aliases: AD10; AD18; ADAM10; CD156c; CDw156; HsT18717; KUZ; MADM; RAK
UniProt ID: (Human) O14672
Entrez Gene ID: (Human) 102
Molecular Function:
protease
in utero embryonic development
protein phosphorylation
membrane protein ectodomain proteolysis
negative regulation of cell adhesion
Notch signaling pathway
Notch receptor processing
integrin-mediated signaling pathway
cell-cell signaling
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
protein processing
extracellular matrix disassembly
positive regulation of cell growth
positive regulation of cell migration
response to tumor necrosis factor
monocyte activation
ephrin receptor signaling pathway
PMA-inducible membrane protein ectodomain proteolysis
constitutive protein ectodomain proteolysis
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