This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 8; ADAM-TS 8; ADAMs; ADAMTS-8; EC 22.214.171.124; EC 126.96.36.199; FLJ41712; metalloendopeptidases; METH-2; METH-8; METH2ADAM-TS METH-8
Gene Aliases: ADAM-TS8; ADAMTS8; METH2
UniProt ID: (Human) Q9UP79
Entrez Gene ID: (Human) 11095
Molecular Function: metalloprotease