The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
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Protein Aliases: acetaldehyde dehydrogenase 5; ADH, beta subunit; Alcohol dehydrogenase 1B; alcohol dehydrogenase 2 (class I), beta polypeptide; Alcohol dehydrogenase subunit beta; aldehyde dehydrogenase 1 family, member B1; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1; Aldehyde dehydrogenase X, mitochondrial; aldehyde reductase; ALDH class 2; All-trans-retinol dehydrogenase [NAD(+)] ADH1B; epididymis secretory protein Li 117
Gene Aliases: ADH1B; ADH2; ALDH1B1; ALDH5; ALDHX; HEL-S-117