|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 322-352 amino acids from the C-terminal region of human ADK|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
Adenosine kinase is an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma¿associated epilepsy.
PA5-13860 was used in immunohistochemistry - paraffin section and western blot to study adenosine deaminase and adenosine kinase expression in human glioma and to determine its correlation with glioma associated epilepsy
|Huang J,He Y,Chen M,Du J,Li G,Li S,Liu W,Long X||Molecular medicine reports (12:6509)||2015|