PA1-24440 detects AEBP1 in Human samples.
PA1-24440 has been successfully used in Western Blot and Immnuohistochemistry (paraffin-embedded sections) procedures. By Western blot, PA1-24440 detects a ~ 131 kDa protein representing AEBP1 in HepG2cell lysate.
PA1-24440 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human AEBP1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The adipocyte enhancer binding protein 1 (AEBP1) is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. AEBP1 may play a role in differentiated vascular smooth muscle cells.
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Protein Aliases: ACLP; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein; FLJ33612
Gene Aliases: ACLP; AEBP1
UniProt ID: (Human) Q8IUX7
Entrez Gene ID: (Human) 165