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Abnova

AGER Recombinant Rabbit Monoclonal Antibody

View all (34) RAGE antibodies

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Product Details

RAB01958

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to human AGER.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-beta peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-kB activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: advanced glycation end-products receptor; advanced glycosylation end product-specific receptor; RAGE-4 ORF3; receptor for advanced glycation end products; receptor for advanced glycosylation end products; sRAGE

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Gene Aliases: RAGE

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UniProt ID: (Mouse) Q62151

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Entrez Gene ID: (Mouse) 11596

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Function(s)
beta-amyloid binding DNA binding RNA binding protein binding signaling receptor activity histone binding identical protein binding S100 protein binding macromolecular complex binding binding, bridging high mobility group box 1 binding advanced glycation end-product binding
Process(es)
response to hypoxia microglial cell activation positive regulation of cytokine production regulation of T cell mediated cytotoxicity negative regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation phagocytosis inflammatory response negative regulation of cell adhesion JAK-STAT cascade learning or memory glucose mediated signaling pathway positive regulation of autophagy negative regulation of endothelial cell migration positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration astrocyte development positive regulation of smooth muscle cell migration positive regulation of signaling negative regulation of signaling positive regulation of cell migration negative regulation of cell migration neuron projection development negative regulation of interleukin-10 production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of collagen biosynthetic process positive regulation of heterotypic cell-cell adhesion intracellular signal transduction positive regulation of locomotion positive regulation of activated T cell proliferation positive regulation of apoptotic process positive regulation of JUN kinase activity positive regulation of neuron apoptotic process transcytosis positive regulation of JNK cascade astrocyte activation positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation regulation of inflammatory response positive regulation of phagocytosis induction of positive chemotaxis positive regulation of DNA metabolic process negative regulation of multicellular organismal process positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotactic protein-1 production protein localization to membrane protein localization to plasma membrane regulation of spontaneous synaptic transmission transport across blood-brain barrier regulation of long-term synaptic potentiation negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression regulation of p38MAPK cascade positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of potassium ion transmembrane transport cellular response to oxygen-containing compound positive regulation of amyloid precursor protein catabolic process negative regulation of blood circulation positive regulation of endothelin production negative regulation of connective tissue replacement involved in inflammatory response wound healing response to amyloid-beta cellular response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of DNA-dependent DNA replication positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process positive regulation of monocyte extravasation regulation of CD4-positive, alpha-beta T cell activation positive regulation of type B pancreatic cell apoptotic process positive regulation of double-strand break repair positive regulation of dendritic cell differentiation
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