S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family.
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Protein Aliases: Acetylation; Adenosylhomocysteinase; AdoHcyase; Hydrolase; NAD; Polymorphism; S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase
Gene Aliases: adoHcyase; AHCY; SAHH
UniProt ID: (Human) P23526
Entrez Gene ID: (Human) 191
Molecular Function: hydrolase