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AHNAK Antibody (H00079026-D01P) in WB
Western Blot analysis of AHNAK expression in transfected 293T cell line (H00079026-T02) by AHNAK MaxPab polyclonal antibody.
Lane 1: AHNAK transfected lysate(16.10 KDa).
Lane 2: Non-transfected lysate.
Lane 1: AHNAK transfected lysate(16.10 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00079026-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AHNAK (NP_076965.2, 1 a.a. approximately 149 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MEKEETTREL LLPNWQGSGS HGLTIAQRDD GVFVQEVTQN SPAARTGVVK EGDQIVGATI YFDNLQSGEV TQLLNTMGHH TVGLKLHRKG DRSPEPGQTW TREVFSSCSS EVVLNTPQPS ALECKDQNKQ KEASSQAGAV SVSTPNAGL
Target Information
AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AHNAK-related; Desmoyokin; MGC5395; Neuroblast differentiation-associated protein AHNAK
Gene Aliases: AHNAK; AHNAKRS; PM227
UniProt ID: (Human) Q09666
Entrez Gene ID: (Human) 79026
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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