This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
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Protein Aliases: activation induced deaminase; AICDA; ARP2; CDA2; cytidine aminohydrolase; epididymis secretory protein Li 284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; single-stranded DNA cytosine deaminase
Gene Aliases: AID; ARP2; CDA2; HEL-S-284; HIGM2