AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
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Protein Aliases: AKR1B1; Aldehyde reductase; aldehyde reductase 1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase
Gene Aliases: ADR; AKR1B1; ALDR1; ALR2; AR
UniProt ID: (Human) P15121
Entrez Gene ID: (Human) 231