Immunogen sequence: MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA LLSCTSHKDY PFHEEF; Positive Samples: HeLa, Jurkat, 293T, A-375, HepG2, Mouse heart; Cellular Location: Cytoplasm
AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
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Protein Aliases: Aldehyde reductase; aldehyde reductase 1; Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene); Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); aldo-keto reductase family 1, member B4 (aldose reductase); Aldose reductase; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase
Gene Aliases: ADR; AKR1B1; Akr1b3; Akr1b4; ALDR1; ALDRED; Alr; ALR-P-I; ALR2; AR; RATALDRED