|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A highly specific 15 amino acid portion of human AKR1B10 (within amino acids 100-150)|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris HCl with 100mM NaCl, 50% glycerol|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:5-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:5-1:50|
|Immunoprecipitation (IP)||5 µg|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody does not cross react with mouse, rat or rabbit.
AKR1B10, also known as Aldo-keto reductase family 1, member B10, AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly expressed in small intestine, colon and adrenal gland. This protein is pathogenically involved in diabetic complications and has been reported that AKR1B10 is overexpressed in human tumors, such as liver, breast, and lung cancer, and may play a critical role in the development and progression of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.