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Invitrogen
AKR1C1/AKR1C2 Recombinant Rabbit Monoclonal Antibody (23GB3175)
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FIGURE: 1 / 4
AKR1C1/AKR1C2 Antibody (MA5-53602) in ICC/IF
Immunocytochemistry analysis of AKR1C1/AKR1C2 in HeLa cells. Nuclei were stained blue with DAPI; AKR1C1/AKR1C2 recombinant monoclonal antibody (Product # MA5-53602) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Product Details
MA5-53602
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB3175
Immunogen
A synthetic peptide of human AKR1C1/AKR1C2 (50-101AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.54 mg/mL
Amount
54 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. And this gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; 3beta-hydroxysteroid 3-dehydrogenase; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; Aldo-keto reductase family 1 member C2; chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; Chlordecone reductase homolog HAKRD; DD-2; DD/BABP; DD1; Dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; Dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III; Dihydrodiol dehydrogenase/bile acid-binding protein; HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; indanol dehydrogenase; oxidoreductase; pseudo-chlordecone reductase; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase; unnamed protein product
Gene Aliases: 2-ALPHA-HSD; 20-ALPHA-HSD; AKR1C-pseudo; AKR1C1; AKR1C2; BABP; C9; DD; DD-2; DD/BABP; DD1; DD1/DD2; DD2; DDH; DDH1; DDH2; H-37; HAKRC; HAKRD; HBAB; MBAB; MCDR2; SRXY8; TDD
UniProt ID: (Human) Q04828, (Human) P52895
Entrez Gene ID: (Human) 1645, (Human) 1646
alditol:NADP+ 1-oxidoreductase activity
estradiol 17-beta-dehydrogenase activity
protein binding
alcohol dehydrogenase (NADP+) activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
testosterone dehydrogenase [NAD(P)] activity
carboxylic acid binding
bile acid binding
3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase activity
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity
3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity
retinoid metabolic process
alcohol metabolic process
lipid metabolic process
prostaglandin metabolic process
xenobiotic metabolic process
digestion
steroid metabolic process
bile acid metabolic process
bile acid and bile salt transport
intestinal cholesterol absorption
epithelial cell differentiation
monocarboxylic acid metabolic process
hormone metabolic process
progesterone metabolic process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
cellular response to jasmonic acid stimulus
positive regulation of reactive oxygen species metabolic process
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of protein kinase B signaling
cellular response to prostaglandin D stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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