This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
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Protein Aliases: 17-beta-HSD 5; 17HSD type 5; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; AKR1C1; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1; aldo-keto reductase family 1, member C1 (aldehyde reductase); aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C6; Chlordecone reductase homolog HAKRC; DD1/DD2; DDH; DDH1; dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; dihydrodiol dehydrogenase isoform DD1; Estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; hydroxysteroid 17-beta dehydrogenase 5; Indanol dehydrogenase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type 5 17beta-hydroxysteroid dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase
Gene Aliases: 2-ALPHA-HSD; 20-ALPHA-HSD; 3alpha-HSD; AKR1C1; Akr1c6; C9; DD1; DD1/DD2; DDH; DDH1; H-37; HAKRC; HBAB; Hsd17b5; MBAB