Invitrogen

AKR1C3 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

View all (15) AKR1C3 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-106891

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human AKR1C3(Accession P42330), corresponding to amino acid residues E291-Y323.
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Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2854555

Product Specific Information

Antibody detects endogenous levels of total AKR1C3.

Target Information

AKR1C3 a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17beta-HSD5; 2-dih; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; Aldo-keto reductase family 1 member C18; Aldo-keto reductase family 1 member C3; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); Chlordecone reductase homolog HAKRb; DD-3; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; dihydrodiol dehydrogenase X; HA1753; HSD1; indanol dehydrogenase; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase

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Gene Aliases: Akr1c18; AKR1C3; DD3; DDH1; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; KIAA0119; PGFS

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UniProt ID: (Human) P42330, (Rat) P51652

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Entrez Gene ID: (Human) 8644, (Rat) 171516

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Function(s)
retinal dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity retinol dehydrogenase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor phenanthrene 9,10-monooxygenase activity dihydrotestosterone 17-beta-dehydrogenase activity prostaglandin H2 endoperoxidase reductase activity prostaglandin D2 11-ketoreductase activity geranylgeranyl reductase activity ketoreductase activity prostaglandin-F synthase activity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity androsterone dehydrogenase activity testosterone dehydrogenase (NAD+) activity testosterone 17-beta-dehydrogenase (NADP+) activity ketosteroid monooxygenase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity indanol dehydrogenase activity delta4-3-oxosteroid 5beta-reductase activity NADP-retinol dehydrogenase activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity oxidoreductase reductase metabolite interconversion enzyme
Process(es)
protein import into nucleus, translocation retinoid metabolic process prostaglandin metabolic process G-protein coupled receptor signaling pathway response to nutrient steroid metabolic process positive regulation of cell proliferation male gonad development cellular response to starvation positive regulation of cell death farnesol catabolic process cyclooxygenase pathway keratinocyte differentiation cellular response to reactive oxygen species progesterone metabolic process retinol metabolic process retinal metabolic process multicellular organismal macromolecule metabolic process daunorubicin metabolic process doxorubicin metabolic process regulation of retinoic acid receptor signaling pathway positive regulation of protein kinase B signaling oxidation-reduction process testosterone biosynthetic process renal absorption cellular response to cadmium ion cellular response to calcium ion cellular response to prostaglandin stimulus cellular response to corticosteroid stimulus cellular response to jasmonic acid stimulus cellular response to prostaglandin D stimulus negative regulation of retinoic acid biosynthetic process regulation of testosterone biosynthetic process positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process progesterone catabolic process parturition regulation of steroid biosynthetic process
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