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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (DPKYQRVELNDGH) corresponding to the N-terminus amino acids of AKR1C4|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-0.3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4; 3-alpha hydroxysteroid dehydrogenase, type I; 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase variant; AKR1C4; aldo-keto reductase family 1, member C4; CDR; CHDR; chlordecone reductase; chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4; DD4; dihydrodiol dehydrogenase 4; dihydrodiol dehydrogenase isozyme DD4; HGNC:387; MGC22581; type I 3-alpha-hydroxysteroid dehydrogenase
3-alpha-HSD; AKR1C4; C11; CDR; CHDR; DD-4; DD4; HAKRA