PA5-28963 targets AKR1D1 in WB applications and shows reactivity with Human samples.
The PA5-28963 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 326 of Human AKR1D1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction.
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Protein Aliases: 3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; Aldo-keto reductase family 1 member D1; beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1); CBAS2; delta 4-3-ketosteroid-5-beta-reductase; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase; SRD5B1; steroid-5-beta-reductase; steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1)
Gene Aliases: 3o5bred; AKR1D1; CBAS2; SRD5B1
UniProt ID: (Human) P51857
Entrez Gene ID: (Human) 6718