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ALX4 Antibody (MA5-26062) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human ovary tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a ALX4 monoclonal antibody (Product # MA5-26062).
Product Details
MA5-26062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1F2
Immunogen
Full length human recombinant protein of ALX4 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723867
Target Information
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aristaless-like homeobox 4; Homeobox protein aristaless-like 4; homeodomain transcription factor ALX4
Gene Aliases: ALX4; CRS5; FND2; KIAA1788
UniProt ID: (Human) Q9H161
Entrez Gene ID: (Human) 60529
skeletal system development
hair follicle development
transcription from RNA polymerase II promoter
muscle organ development
post-embryonic development
anterior/posterior pattern specification
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic digit morphogenesis
regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
embryonic skeletal system morphogenesis
palate development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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