AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.
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Protein Aliases: Angiomotin; angiomotin p130 isoform; angiomotin p80 isoform
Gene Aliases: AMOT; KIAA1071
UniProt ID: (Human) Q4VCS5
Entrez Gene ID: (Human) 154796