A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits.
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Protein Aliases: Anaphase-promoting complex subunit 2; APC2; Cyclosome subunit 2; expressed during mesenchymal induction 4; induced during mesenchymal induction 4
Gene Aliases: 9230107K09Rik; AL024279; ANAPC2; APC2; Emi4; Imi4; KIAA1406; mKIAA1406