Invitrogen

ANO6 (extracellular) Polyclonal Antibody

View all (6) ANO6 antibodies

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ANO6 (extracellular) Antibody in Western Blot (WB) — Western Blot analysis of ANO6 was performed in human THP-1 monocytic leukemia cell line lysate (lanes 1 and 3) and human MEG-01 megakaryoblastic leukemia cell line lysate (lanes 2 and 4). Lane 1,2: ANO6 (extracellular) Antibody (Product # PA5-111760) at a dilution of 1:200. Lane 3,4: ANO6 (extracellular) Antibody preincubated with the negative control antigen.

ANO6 (extracellular) Antibody in Western Blot (WB) — Western Blot analysis of ANO6 was performed in mouse liver lysate (lanes 1 and 3) and rat liver membranes (lanes 2 and 4). Lane 1,2: ANO6 (extracellular) Antibody (Product # PA5-111760) at a dilution of 1:200. Lane 3,4: ANO6 (extracellular) Antibody preincubated with the negative control antigen.

ANO6 (extracellular) Antibody in Flow Cytometry (Flow) — Flow Cytometry analysis of ANO6 in live human MEG-01 megakaryoblastic leukemia cell line. Black: Cells. Pink: Cells and goat-anti-rabbit-FITC. Green: Cells, ANO6 (extracellular) Antibody (Product # PA5-111760), and goat-anti-rabbit-FITC.

Product Details

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

5 µg

-

Western Blot (WB)

1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide corresponding to amino acid residues 487-500 of human ANO6 (2nd extracellular loop)

Conjugate

Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

RRID

AB_2857170

Product Specific Information

Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Peptide sequence is: (C)KLPKNIN GTDPIQK

Homology: Mouse, rat - 12/14 amino acid residues identical.

Target Information

May act as a calcium-activated chloride channel.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Anoctamin-6; SCAN channel; Small-conductance calcium-activated nonselective cation channel; Transmembrane protein 16F

Gene Aliases: 2900059G15Rik; AA407480; ANO6; AW554778; BDPLT7; F730003B03Rik; SCTS; TMEM16F

UniProt ID: (Human) Q4KMQ2, (Mouse) Q6P9J9

Entrez Gene ID: (Human) 196527, (Rat) 315272, (Mouse) 105722

dendritic cell chemotaxis activation of blood coagulation via clotting cascade cation transport chloride transport lipid transport blood coagulation phospholipid scrambling positive regulation of bone mineralization bleb assembly ion transmembrane transport positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway bone mineralization involved in bone maturation sodium ion transmembrane transport positive regulation of apoptotic process negative regulation of cell volume pore complex assembly positive regulation of phagocytosis, engulfment calcium activated phosphatidylserine scrambling calcium activated phosphatidylcholine scrambling calcium activated galactosylceramide scrambling calcium ion transmembrane transport positive regulation of monocyte chemotaxis phosphatidylserine exposure on blood platelet positive regulation of potassium ion export chloride transmembrane transport regulation of anion transmembrane transport positive regulation of endothelial cell apoptotic process phospholipid transport regulation of anion transport calcium activated phospholipid scrambling phosphatidylserine exposure on apoptotic cell surface cation transmembrane transport transport ion transport regulation of ion transmembrane transport

Process(es)

calcium activated cation channel activity intracellular calcium activated chloride channel activity voltage-gated ion channel activity voltage-gated chloride channel activity protein binding phospholipid scramblase activity protein homodimerization activity molecular_function chloride channel activity