|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 161-206 of human ANP32C|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 27 kDa.
Purity is >95% by SDS-PAGE.
ANP32C (acidic (leucine-rich) nuclear phosphoprotein 32 family, member C), also known as PP32R1 (phosphoprotein 32-related protein 1) or tumorigenic protein pp32r1, is a 234 amino acid protein that contains 4 leucine-rich repeats and belongs to the ANP32 family. ANP32C shares 87.7% amino acid sequence identity with ANP32A, a tumor suppressor that inhibits a variety of cancers, such as prostate and breast cancers. Although similar to ANP32A, ANP32C is tumorigenic and is expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. ANP32C is also expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines, but not in normal protastic tissue, and may also modulate the oncogenic potential of human prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.