Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
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Protein Aliases: Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANX1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; LPC1; p35; Phospholipase A2 inhibitory protein
Gene Aliases: ANX1; ANXA1; LPC1
UniProt ID: (Human) P04083
Entrez Gene ID: (Human) 301