Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANAX1; Annexin A1; Annexin Ac2-26; Annexin I; annexin I (lipocortin I); Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1
Gene Aliases: ANX1; ANXA1; LPC1
UniProt ID: (Human) P04083
Entrez Gene ID: (Human) 301
Molecular Function: calcium-binding protein