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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Recombinant N-terminal fragment of APC.|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.05M sodium phosphate with 0.2% gelatin|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||5 µg/ml|
|Immunohistochemistry (Frozen) (IHC (F))||4-6 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||4-6 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25884 detects APC from human, mouse, and rat samples.
MA1-25884 has been successfully used in immunohistochemistry (paraffin), immunofluorescence, and immunocytochemsitry procedures.
The MA1-25884 immunogen is recombinant N-terminal fragment of APC.
This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; Adenomatous Polyposis Coli; adenomatous polyposis coli protein; APC; deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; multiple intestinal neoplasia; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
AI047805; APC; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC