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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of human Aph-1a|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EphB signaling regulates target innervation in the developing and deafferented auditory brainstem.
||Nakamura PA,Hsieh CY,Cramer KS||Developmental neurobiology (72:1243)||2012|
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
||Tabuchi K,Chen G,Südhof TC,Shen J||The Journal of neuroscience : the official journal of the Society for Neuroscience (29:7290)||2009|
APH-1a, APH-1A, APH-1, 6530402N02Rik, RP4-790G17.3, CGI-78
anterior pharynx defective 1 homolog A, aph-1alpha, gamma-secretase subunit APH-1A, presenilin-stabilization factor, RP4-790G17.3, 6530402N02Rik, APH-1, APH-1A, CGI-78