|Western Blot (WB)||0.05-0.1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (HVTDRSDARLQYG) corresponding to the internal amino acids of APH1A|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
APH1 is a multipass transmembrane protein that interacts with presenilin and nicastrin as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein and Notch .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1 homolog A (C. elegans); aph-1 homolog A, gamma secretase subunit; APH-1A; Aph-1alpha; APH1A; APH1A gamma secretase subunit; CGI-78; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor
Gene Aliases: 6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3
Entrez Gene ID: (Human) 51107
Molecular Function: enzyme modulator
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