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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (HVTDRSDARLQYG) corresponding to the internal amino acids of APH1A|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.05-0.1 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
APH1 is a multipass transmembrane protein that interacts with presenilin and nicastrin as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein and Notch .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1 homolog A (C. elegans); aph-1 homolog A, gamma secretase subunit; APH-1A; aph-1alpha; APH1A; APH1A gamma secretase subunit; CGI-78; presenilin-stabilization factor
6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; UNQ579/PRO1141