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The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
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Protein Aliases: ARNT-like protein 1, brain and muscle; Aryl hydrocarbon receptor nuclear translocator-like protein 1; basic-helix-loop-helix-PAS orphan MOP3; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; bHLHe5; Brain and muscle ARNT-like 1; CG8727 PA; Class E basic helix-loop-helix protein 5; cycle; Member of PAS protein 3; member of PAS superfamily 3; MGC47515; PAS domain-containing protein 3; testis tissue sperm-binding protein Li 50e
Gene Aliases: ARNTL; BHLHE5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
UniProt ID: (Human) O00327
Entrez Gene ID: (Human) 406
Molecular Function: basic helix-loop-helix transcription factor