The Arp2/3 (Actin-related protein 2/3) complex consists of seven subunits, all of which are actin-related proteins. The complex is involved in the control of actin polymerization and in mediating the formation of branched actin networks. p16-ARC, also known as ARPC5 (Actin-related protein 2/3 complex subunit 5) or ARC16 (Arp2/3 complex 16 kDa subunit), is a 151 amino acid subunit of the Arp2/3 complex. Thought to play a role in maintaining the integrity of Arp2/3, p16-ARC is a substrate for MAPKAPK-2 which, through phosphorylation of p16-ARC, may participate in Arp2/3 regulatory functions and remodeling of the Actin cytoskeleton. Two isoforms of p16-ARC exist due to alternative splicing events.
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Protein Aliases: actin related protein 2/3 complex subunit 5, 16kDa; actin related protein 2/3 complex, subunit 5, 16kDa; Actin-related protein 2/3 complex subunit 5; ARC16; Arp2/3 complex 16 kDa subunit; Arp2/3 protein complex subunit p16; dJ127C7.3; p16-ARC
Gene Aliases: ARC16; ARPC5; dJ127C7.3; p16-Arc
UniProt ID: (Human) O15511
Entrez Gene ID: (Human) 10092