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ARRB1 Monoclonal Antibody (OTI2B3), TrueMAB™

View all (34) beta Arrestin 1 antibodies

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ARRB1 Monoclonal Antibody (OTI2B3), TrueMAB™

Product Details

TA812546

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI2B3

Immunogen

Full length human recombinant protein of human ARRB1 (NP_004032) produced in E.coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol, 1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Dilute in PBS (pH7.3) if necessary. Stable for 12 months from date of receipt.

Target Information

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: arrestin; arrestin 2; beta-arrestin; beta-arrestin1; non-visual arrestin-2; unnamed protein product

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Gene Aliases: 1200006I17Rik; ARB1; ARR1; BARRES; G430100A01Rik

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UniProt ID: (Human) P49407, (Mouse) Q8BWG8, (Rat) P29066

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Entrez Gene ID: (Human) 408, (Mouse) 109689, (Rat) 25387

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Function(s)
G-protein coupled receptor binding transcription coactivator activity histone acetyltransferase activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity GTPase activator activity insulin-like growth factor receptor binding protein binding enzyme binding protein binding, bridging mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding angiotensin receptor binding binding, bridging arrestin family protein binding receptor binding clathrin binding estrogen receptor binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding follicle-stimulating hormone receptor binding V2 vasopressin receptor binding AP-2 adaptor complex binding clathrin adaptor activity ion channel binding protein phosphorylated amino acid binding phosphoprotein binding
Process(es)
cellular glucose homeostasis positive regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization positive regulation of receptor internalization regulation of transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process signal transduction cell surface receptor signaling pathway sensory perception protein ubiquitination negative regulation of protein ubiquitination negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of Rho protein signal transduction intraciliary retrograde transport positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Notch signaling pathway positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of ERK1 and ERK2 cascade protein localization to nonmotile primary cilium positive regulation of intracellular signal transduction negative regulation of protein localization to ciliary membrane negative regulation of protein phosphorylation regulation of transcription, DNA-templated endocytosis G-protein coupled receptor signaling pathway phototransduction regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of signal transduction positive regulation of protein ubiquitination regulation of inositol trisphosphate biosynthetic process negative regulation of GTPase activity follicle-stimulating hormone signaling pathway negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process negative regulation of ERK1 and ERK2 cascade adenylate cyclase-modulating G-protein coupled receptor signaling pathway response to xenobiotic stimulus regulation of protein ubiquitination response to morphine sensory perception of touch
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