Invitrogen

AS160 Monoclonal Antibody (8A11A2)

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Datasheet

Protocols

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AS160 Antibody in Western Blot (WB) — Western blot analysis of AS160 in HEK293 (1) and TBC1D4 cell lysate. Samples were incubated with AS160 monoclonal antibody (Product # MA5-31921) using a dilution of 1:500-1:2000.

AS160 Antibody in Flow Cytometry (Flow) — Flow cytometry of AS160 in HeLa cells (green). Sample was incubated with AS160 monoclonal antibody (Product # MA5-31921) using a dilution of 1:200-1:400 followed by negative control (red).

AS160 Antibody in ELISA (ELISA) — ELISA analysis of AS160 in Control Antigen (black line, 100 ng); Antigen (purple line, 10 ng); Antigen (blue line, 50 ng); Antigen (red line, 100 ng). Samples were incubated with AS160 monoclonal antibody (Product # MA5-31921) using a dilution of 1:10,000.

Product Details

MA5-31921

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Flow Cytometry (Flow)	1:200-1:400	-
ELISA (ELISA)	1:10,000	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	8A11A2
Immunogen	Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. coli. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein G
Storage buffer	PBS
Contains	0.05% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2787544

Target Information

AS160 (TBC1D4) is a GTPase-activiting protein for RAB2A, RAB8A, RAB10, and RAB14. The isoform 2 version of this protein promotes the insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane. This movement increases glucose uptake. Mutations associated with the gene cause Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Akt substrate of 160 kDa; AS160; DKFZp779C0666; OTTHUMP00000040818; RP11-159J2.1; RP11-159J2.3; TBC (Tre-2, BUB2, CDC16) domain-containing protein; TBC Tre-2; TBC1 domain family member 4; TBC1 domain family, member 4

Gene Aliases: AS160; KIAA0603; NIDDM5; TBC1D4

UniProt ID: (Human) O60343

Entrez Gene ID: (Human) 9882

Molecular Function: GTPase-activating protein

Function(s)

intracellular protein transport vesicle-mediated transport regulation of vesicle fusion negative regulation of vesicle fusion cellular response to insulin stimulus membrane organization activation of GTPase activity

Process(es)

GTPase activator activity Rab GTPase binding

AS160 Monoclonal Antibody (8A11A2)

Product Details

MA5-31921

Western Blot (WB)

Flow Cytometry (Flow)

ELISA (ELISA)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

RRID

Target Information

References (0)

Bioinformatics

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