MA1-149-A647 was produced in Armenian hamster and detects ATG9 in human, rat and mouse samples. In Immunofluorescence applications, MA1-149A-647 shows accumulation and redestribution of ATG9 in response to starvation-induced autophagosome assembly.
Autophagy is an important process associated with infectious disease, neurodegeneration, cancer and the maintenance of cellular homeostasis. ATG9 is an essential component of the autophagy machinery and is found on autophagosomes. ATG9 forms a cycling complex with ATG2 and ATG18, which is thought to constantly deliver lipids from source to growing autophagosomes during early autophagosome assembly. ATG9 is a multi-spanning membrane protein and cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. The detection of this protein provides important information about cell health and survival.
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Protein Aliases: APG9 Autophagy 9-Like 1; APG9-Like 1; APG9L1; ATG 9A; ATG9 Autophagy Related 9 Homolog A; autophagy 9-like 1 protein; autophagy protein 9; Autophagy Related 9A; autophagy-related 9-like 1; autophagy-related 9A; Autophagy-related protein 9A; FLJ22169; mATG9; MGD3208
Gene Aliases: APG9L1; ATG9A; mATG9; MGD3208
UniProt ID: (Human) Q7Z3C6
Entrez Gene ID: (Human) 79065