Positive Control: A549 cell lysate, CRC cell lysate, Hela cell lysate, Wild-type A549 whole cell lysates, Hela, A549, CRC, human thyroid tissue, human breast carcinoma tissue, mouse thyroid tissue, mouse kidney tissue.
Subcellular Location: Cytoplasm, nucleoplasm.
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACL; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; Citrate cleavage enzyme
Gene Aliases: A730098H14Rik; ACL; ACLY; ATPCL; AW538652; CLATP
Molecular Function: transferase