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ATP1A1/2 Monoclonal Antibody (3D8G1)

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ATP1A1/2 Monoclonal Antibody (3D8G1)

Product Details

68505-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:50,000
-

Immunocytochemistry (ICC/IF)

1:500-1:2,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3D8G1

Immunogen

ATP1A1/2 fusion protein Ag10489
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

75 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH EADTTEDQSG ATFDKRSPTW TALSRIAGLC NRAVFKAGQE NISVSKRDTA GDASESALLK CIELSCGSVR KMRDRNPKVA EIPFNSTNKY QLSIHEREDS PQSHVLVMKG APERILDRCS TILVQGKEIP LDKEMQDAFQ NAYMELGGLG ERVLGFCQLN LPSGKFPRGF KFDTDELNFP TEKLCFVGLM SMIDPPRAAV PDAVGKCRSA GIKVIMVTGD HPITAKAIAK GVGIISEGNE TVEDIAARLN IPMSQVNPRE AKACVVHGSD LKDMTSEQLD EILKNHTEIV FARTSPQQKL IIVE

Target Information

ATP1A1/2 is the catalytic component of the active enzyme Na+/K+-ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. The Na+/K+-ATPase is composed of a larger catalytic alpha-subunit (~110 kDa) and a small beta-subunit (~55 kDa). The alpha subunit has four isoforms identified to date: alpha 1, alpha 2, alpha 3 and alpha 4.The alpha 1 isoform is expressed ubiquitously but the alpha 2 isoform is present largely in the skeletal muscle, heart and vascular smooth muscle. The alpha 3 isoform is found almost exclusively in neurons and ovaries. The alpha 4 isoform is expressed in sperm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: (Na+ and K+) ATPase, alpha catalytic subunit precursor; (Na+ and K+) ATPase, alpha+ catalytic subunit precursor; (Na+, K+)-ATPase alpha-subunit; ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 1; ATPase, Na+K+ transporting, alpha 2; G00-119-711; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-1 subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+ ,K+ -ATPase alpha subunit; Na+ /K+ ATPase alpha 1 subunit; Na+ K+ ATPase alpha subunit; Na+, K+-ATPase beta-subunit precursor; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ transporting alpha 1 polypeptide; Na+/K+ transporting alpha 2 polypeptide; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha 2 subunit; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na,K-ATPase subunit alpha-B; Na,K-ATPase, alpha-subunit; sodium pump subunit alpha-1; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium-ATPase, alpha 1 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; unnamed protein product

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Gene Aliases: Atpa-1; Atpa-3; CMT2DD; DEE98; FARIMPD; FHM2; HOMGSMR2; MHP2; mKIAA0778; Nkaa1b; RATATPA2

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UniProt ID: (Human) P05023, (Pig) P05024, (Human) P50993, (Pig) D2WKD8, (Mouse) Q8VDN2, (Rat) P06685, (Mouse) Q6PIE5, (Rat) P06686

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Entrez Gene ID: (Human) 476, (Pig) 397481, (Human) 477, (Pig) 396828, (Mouse) 11928, (Rat) 24211, (Mouse) 98660, (Rat) 24212

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Function(s)
nucleotide binding sodium:potassium-exchanging ATPase activity protein binding ATP binding potassium-transporting ATPase activity phosphatase activity ATPase activity potassium ion binding sodium ion binding ion channel binding chaperone binding steroid hormone binding ATPase binding steroid binding cation-transporting ATPase activity protein heterodimerization activity protein kinase binding protein domain specific binding ankyrin binding ADP binding phosphatidylinositol 3-kinase binding primary active transporter transporter
Process(es)
regulation of sodium ion transport potassium ion transport cellular sodium ion homeostasis osmosensory signaling pathway establishment or maintenance of transmembrane electrochemical gradient cellular cation homeostasis cellular potassium ion homeostasis sodium ion transmembrane transport sodium ion export from cell sodium ion homeostasis relaxation of cardiac muscle cellular response to steroid hormone stimulus potassium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction hydrogen ion transmembrane transport response to glycoside potassium ion import across plasma membrane transmembrane transport neurotransmitter uptake behavioral fear response regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process sodium ion transport regulation of muscle contraction regulation of striated muscle contraction cell communication blood circulation regulation of heart contraction regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion response to auditory stimulus amygdala development olfactory cortex development response to nicotine locomotory exploration behavior locomotion negative regulation of heart contraction positive regulation of heart contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic cardiac muscle contraction cellular response to mechanical stimulus regulation of cardiac muscle cell contraction membrane depolarization during cardiac muscle cell action potential cation transmembrane transport transport across blood-brain barrier negative regulation of calcium ion transmembrane transport regulation of blood pressure response to xenobiotic stimulus negative regulation of glucocorticoid biosynthetic process positive regulation of striated muscle contraction membrane hyperpolarization energy coupled proton transmembrane transport, against electrochemical gradient regulation of smooth muscle contraction adult locomotory behavior visual learning response to mechanical stimulus neuronal action potential propagation regulation of vasoconstriction L-ascorbic acid metabolic process response to potassium ion fear response negative regulation of striated muscle contraction membrane depolarization regulation of cardiac muscle contraction by calcium ion signaling
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