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Product Details
MA5-32898
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2-E7
Immunogen
Recombinant protein within mouse ATRX aa 2236-2416
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 40% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2802533
Target Information
ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha thalassemia/mental retardation syndrome (X-linked); ATP-dependent helicase ATRX; helicase 2; Heterochromatin protein 2; HP1 alpha-interacting protein; HP1-BP38 protein; RP5-875J14.1; Transcriptional regulator ATRX; X-linked nuclear protein
Gene Aliases: 4833408C14Rik; AI447451; ATR2; Atrx; DXHXS6677E; HP1-BP38; Hp1bp2; Hp1bp38; MRXS3; Rad54; RAD54L; XH2; Xnp; ZNF-HX
UniProt ID: (Mouse) Q61687
Entrez Gene ID: (Mouse) 22589
nucleotide binding
DNA binding
chromatin binding
helicase activity
protein binding
ATP binding
zinc ion binding
DNA translocase activity
hydrolase activity
methylated histone binding
histone binding
metal ion binding
chromo shadow domain binding
DNA-binding transcription factor
gene-specific transcriptional regulator
DNA repair
nucleosome assembly
DNA replication-independent nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
spermatogenesis
positive regulation of nuclear cell cycle DNA replication
chromatin modification
DNA damage response, signal transduction by p53 class mediator
forebrain development
replication fork processing
positive regulation of telomere maintenance
post-embryonic forelimb morphogenesis
multicellular organism growth
positive regulation of transcription from RNA polymerase II promoter
Sertoli cell development
seminiferous tubule development
cellular response to hydroxyurea
negative regulation of telomeric RNA transcription from RNA pol II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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