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Product Details
710204
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
11HCLC
Immunogen
Peptide corresponding to amino acids 319-332 of human Axis Inhibitor Protein 1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2532622
Product Specific Information
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Target Information
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; protein phosphatase 1, regulatory subunit 49
Gene Aliases: AXIN; AXIN1; PPP1R49
UniProt ID: (Human) O15169
Entrez Gene ID: (Human) 8312
signal transducer activity
GTPase activator activity
protein binding
beta-catenin binding
enzyme binding
protein kinase binding
receptor signaling complex scaffold activity
ubiquitin protein ligase binding
protein complex scaffold
identical protein binding
protein homodimerization activity
SMAD binding
armadillo repeat domain binding
I-SMAD binding
scaffold/adaptor protein
optic placode formation
positive regulation of protein phosphorylation
apoptotic process
activation of JUN kinase activity
determination of left/right symmetry
cell death
dorsal/ventral axis specification
positive regulation of peptidyl-threonine phosphorylation
Wnt signaling pathway
forebrain anterior/posterior pattern specification
Wnt-activated signaling pathway involved in forebrain neuron fate commitment
negative regulation of Wnt signaling pathway
olfactory placode formation
cytoplasmic microtubule organization
positive regulation of protein ubiquitination
activation of protein kinase activity
positive regulation of peptidyl-serine phosphorylation
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of catenin import into nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of GTPase activity
cellular protein complex assembly
negative regulation of fat cell differentiation
positive regulation of protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
embryonic eye morphogenesis
axial mesoderm formation
positive regulation of ubiquitin-protein transferase activity
muscle cell development
canonical Wnt signaling pathway
embryonic skeletal joint morphogenesis
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
cellular response to organic cyclic compound
negative regulation of canonical Wnt signaling pathway
Wnt signaling pathway involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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