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Proteintech
Acetylcholinesterase Polyclonal Antibody
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Product Details
17975-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Acetylcholinesterase Fusion Protein Ag12146 (1-351 aa encoded by BC094752)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ACHAAMRPP QCLLHTPSLA SPLLLLLVWL LGGGVGAEGR EDAELLVTVR GGRLRGIRLK TPGGPVSAFL GIPFAEPPMG PRRFLPPEPK QPWSGVVDAT TFQSVCYQYV DTLYPGFEGT EMWNPNRELS EDCLYLNVWT PYPRPTSPTP VIVWIYGGGF YSGASSLDVY DGRFLVQAER TVLVSMNYRV GAFGFLALPG SREAPGNVGL LDQRLALQWV QENVAAFGGD PTSVTLFGES AGAASVGMHL LSPPSRGLFH RAVLQSGAPN GPWATVGMGE ARRRATQLAH LVGCPPGGTG GNDTELVACL RTRPAQVLVN HEWHVLPQES VFRFSFVPVV DGDFLSD (1-351 aa encoded by BC094752)
Target Information
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. The Protein is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acetylcholinesterase; acetylcholinesterase (Cartwright blood group); AChE; apoptosis-related acetylcholinesterase; EC 3.1.1.7; glycolipid-anchored form of acetylcholinesterase; OTTHUMP00000211349; OTTHUMP00000211356; unnamed protein product; Yt blood group
Gene Aliases: ACEE; ACHE; ARACHE; N-ACHE; YT
UniProt ID: (Human) P22303, (Mouse) P21836, (Rat) P37136
Entrez Gene ID: (Human) 43, (Mouse) 11423, (Rat) 83817
beta-amyloid binding
acetylcholinesterase activity
cholinesterase activity
protein binding
collagen binding
hydrolase activity
serine hydrolase activity
acetylcholine binding
identical protein binding
protein homodimerization activity
laminin binding
carboxylic ester hydrolase activity
choline binding
protein self-association
esterase
acetylcholine catabolic process in synaptic cleft
regulation of receptor recycling
osteoblast development
acetylcholine catabolic process
cell adhesion
nervous system development
synapse assembly
receptor internalization
negative regulation of synaptic transmission, cholinergic
amyloid precursor protein metabolic process
positive regulation of protein secretion
retina development in camera-type eye
acetylcholine receptor signaling pathway
positive regulation of cold-induced thermogenesis
acetylcholine metabolic process
choline metabolic process
neurotransmitter catabolic process
neurotransmitter receptor biosynthetic process
positive regulation of axonogenesis
positive regulation of dendrite morphogenesis
protein tetramerization
neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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