HYB 111-05-02 has specificity for human acetylcholinesterase. No cross-reaction is seen with human BtChE, or with AChE from flounder or Torpedo marmorata.
HYB 111-05-02 has been successfully used in ELISA and Western blotting techniques. HYB 111-05-02 reacts with both G2-and G4-AChE (native detergent soluble) in ELISA and EAIA using the antibody as capture antibody. HYB 111-05-02 reacts 17 times stronger with human brain AChE than with human erythrocyte AChE.
The HYB 111-05-02 immunogen is brain acetylcholinesterase, human, purified and detergent solubilized.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Acetylcholinesterase (AChE) is an enzyme located in the postsynaptic membrane and in the muscle endplates,
where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular
mass of ~320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of ~170 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acetylcholinesterase; acetylcholinesterase (Yt blood group); AChE; apoptosis-related acetylcholinesterase; EC 188.8.131.52; YT; Yt blood group
Gene Aliases: ACEE; ACHE; ARACHE; N-ACHE; YT
UniProt ID: (Human) P22303
Entrez Gene ID: (Human) 43