ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acrosin; Acrosin heavy chain; acrosin light and heavy chain prepropeptide; Acrosin light chain; preproacrosin; proacrosin
Gene Aliases: ACR; ACRS
UniProt ID: (Human) P10323
Entrez Gene ID: (Human) 49