MA1-24908 detects Actin from human, mouse, rat, Xenopus laevis, bovine, carp, canine, goat, guinea pig, hamster, porcine, rabbit, and ovine samples.
MA1-24908 has been successfully used in immunofluorescence, immunohistochemistry (frozen and paraffin) procedures.
The MA1-24908 immunogen is a synthetic peptide corresponding to the C-terminal residues S G P S I V H R K C F of human Actin attached to a Multiple Antigen Peptide (MAP) backbone.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACTA; actin alpha 1; actin, alpha 1, skeletal muscle; actin, alpha 2, smooth muscle, aorta; Actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; alpha 1 skeletal muscle actin; alpha actin; alpha actin 1; alpha actin 2; Alpha-actin-1; Alpha-actin-2; alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; ASMA; Cell growth-inhibiting gene 46 protein; CFTD; CFTD1; CFTDM; cytoplasmic beta-actin; MPFD; NEM1; NEM2; NEM3; nemaline myopathy type 3; RP5-1068B5.2; skeletal alpha actin; smooth muscle alpha-actin; vascular smooth muscle alpha-actin
Gene Aliases: 0610041G09Rik; a-SMA; AA959943; AAT6; ACT-4; ACTA; Acta-2; ACTA1; ACTA2; Acts; ACTSA; Actsk-1; ACTVS; alphaSMA; ASMA; BOS_23286; BOS_23966; CFTD; CFTD1; CFTDM; GIG46; I79_002310; MPFD; MYMY5; NEM1; NEM2; NEM3; SHPM; SMalphaA; XELAEV_18029136mg
Entrez Gene ID: (Goat) 102182476, (Human) 58, (Bovine) 281592, (Pig) 100154254, (Sheep) 101107662, (Dog) 488984, (Pig) 733615, (Rabbit) 100009271, (Goat) 102191486, (Bovine) 515610, (Human) 59, (Sheep) 101121051, (Dog) 477587, (Guinea pig) 100716933, (Chinese hamster) 100768972, (Mouse) 11459, (Rat) 29437, (Rat) 81633, (Mouse) 11475, (Guinea pig) 100722917, (Rabbit) 100009506, (Xenopus) 432314