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|Tested species reactivity||Bovine, Dog, Chicken, Fruit fly, Cat, Guinea pig, Human, Leech, Mouse, Sheep, Pig, Rabbit, Rat|
|Published species reactivity||Dog, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to N-terminus of human beta-actin|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 4 publications below|
PA5-16914 targets Actin Beta in IHC (P) and WB applications and shows reactivity with Bovine, Canine, Chicken, Drosophila, Feline, Guinea Pig, Human, Leech, mouse, Ovine, Porcine, Rabbit, and Rat samples.
The PA5-16914 immunogen is synthetic peptide corresponding to N-terminus of human beta-actin.
The two major cytoskeletal proteins implicated in cell motility are actin and myosin. There are three alpha-actin (skeletal, cardiac, and smooth muscle), one beta-actin (beta nonmuscle), and two gamma-actins (gamma-smooth nuscle and gamma-nonmuscle). Antibody to beta-actin provides a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Age-dependent decline in dental pulp regeneration after pulpectomy in dogs.
PA5-16914 was used in western blot to study the cellular mechanisms underlying the age-dependent decrease in the regenerative capacity of canine dental pulp
|Iohara K,Murakami M,Nakata K,Nakashima M||Experimental gerontology (52:39)||2014|
The use of granulocyte-colony stimulating factor induced mobilization for isolation of dental pulp stem cells with high regenerative potential.
PA5-16914 was used in western blot to develop a method for the isolation of high regenerative potential dental pulp stem cells based on G-CSF-induced migration
|Murakami M,Horibe H,Iohara K,Hayashi Y,Osako Y,Takei Y,Nakata K,Motoyama N,Kurita K,Nakashima M||Biomaterials (34:9036)||2013|
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.
PA5-16914 was used in western blot to study age-related macular degeneration and the roles played by VEGF-A and the NLRP3 inflammasome
|Marneros AG||Cell reports (4:945)||2013|
Hsp90-targeted miRNA-liposomal formulation for systemic antitumor effect.
PA5-16914 was used in western blot to study the anti-tumor effects of a system for the GR-mediated delivery of anti-Hsp90 miRNA
|Pore SK,Choudhary A,Rathore B,Ganguly A,Sujitha P,Kumar CG,Agawane SB,Kumar JM,Scaria V,Pillai B,Banerjee R||Biomaterials (34:6804)||2013|
actin, beta; actin, beta, cytoplasmic; actin, cytoplasmic 1; Atcb; beta actin; beta cytoskeletal actin; beta-actin; Cap Z; capZ beta; cytoplasmic 1; cytoplasmic beta-actin; F-actin capping protein beta subunit; gamma non-muscle actin; PS1TP5-binding protein 1
ACT-5; ACTB; actin; Actx; Bact; beta-actin; BOS_22932; BRWS1; E430023M04Rik; PS1TP5BP1; RCJMB04_4h19