Invitrogen

Activin A Recombinant Rabbit Monoclonal Antibody (105)

View all (22) Activin A antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Product Details

MA5-29416

Applications

Tested Dilution

Publications

ELISA (ELISA)

1:5,000-1:10,000

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

105

Immunogen

Recombinant Mouse Inhibin beta A/INHBA protein (Met1-Ser424)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

RRID

AB_2785282

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Mouse Inhibin beta A/INHBA.

Target Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activin beta-A chain; Inhibin beta A chain

Gene Aliases: Inhba

UniProt ID: (Mouse) Q04998

Entrez Gene ID: (Mouse) 16323

Molecular Function: growth factor

Function(s)

G1/S transition of mitotic cell cycle ovarian follicle development mesoderm formation hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter cell cycle arrest negative regulation of cell proliferation male gonad development positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway endodermal cell differentiation growth odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion regulation of apoptotic process regulation of MAPK cascade positive regulation of erythrocyte differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of follicle-stimulating hormone secretion mesodermal cell differentiation cell development negative regulation of hair follicle development palate development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Process(es)

receptor binding cytokine activity transforming growth factor beta receptor binding hormone activity growth factor activity peptide hormone binding inhibin binding identical protein binding protein heterodimerization activity type II activin receptor binding