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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 475-525 of human ACVR1.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||3-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
By Western blot, this antibody detects a ~54 kDa band representing Activin Receptor Type IA.
Additional non-specific bands at ~14 and 27 kDa may also be detected in human kidney samples.
Suggested positive control: human kidney protein or tissue.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; activin type I receptor; ACTR-I; ACVR1; ALK2-B; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I
ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI