PA5-28354 targets Adenylate kinase 1 in WB applications and shows reactivity with Human and mouse samples.
The PA5-28354 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 188 of Human Adenylate kinase 1.
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Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.
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Protein Aliases: Adenylate kinase isoenzyme 1; Adenylate monophosphate kinase; AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; cytosolic adenylate kinase; Myokinase; testis secretory sperm binding protein Li 58j
Gene Aliases: Ak-1; AK1; B430205N08Rik; HTL-S-58j