PA5-28611 targets Adenylate kinase 2 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-28611 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 239 of Human Adenylate kinase 2.
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Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Two transcript variants encoding distinct isoforms have been identified for this gene.
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Protein Aliases: adenylate kinase 2; Adenylate kinase 2, mitochondrial; Adenylate kinase 2, mitochondrial, N-terminally processed; adenylate kinase isoenzyme 2; adenylate kinase isoenzyme 2, mitochondrial; Adenylate monophosphate kinase; ADK2; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; mitochondrial; testis secretory sperm-binding protein Li 220n
Gene Aliases: ADK2; Ak-2; AK2; D4Ertd220e